人垂体瘤转化基因在胰腺恶性肿瘤中的表达及其意义

Expression of Human H-PTTG in Human Pancreatic Carcinoma:Significance and Relationships to Clinical Tumor Behavior

目的:探讨人垂体瘤转化基因(h-PTTG)在胰腺恶性肿瘤中的表达与病理分化与临床分期之间的关系。方法:运用免疫组织化学染色的方法观察h-PTTG在45例胰腺癌及癌旁组织、15例胰腺良性肿瘤、8例正常胰腺组织中的表达情况。结果:h-PTTG在45例胰腺癌组织中的阳性表达率为88.9%与癌旁组织、正常胰腺组织和胰腺良性肿瘤中的表达差异有统计学意义(P<0.05)。h-PTTG的表达强弱与患者肿瘤大小、淋巴转移无关(P>0.05),与肿瘤局部侵润和肿瘤分化程度相关(P<0.05)。结论:h-PTTG在胰腺癌中高表达提示其与胰腺癌的恶性程度相关,并且在胰腺癌的侵润转移等生物学行为中起促进作用。

Objective： This objective is to investigate expression of h-PTTG and relationship with clinical pathologic characteristics in pancreatic carcinoma.Methods：h-PTTG was detected by S-P immunohistochemical staining in 45 case of pancreatic carcinoma, using the same way in 15 ease of pancreatic benign tumor and 8 case of pancreatic normal tissue as contrast.Results：The positive rate of h-PTTG protein in 45 cases of pancreatic ductual carcinoma tissue was 88.9%.Expression of h-PTTG in pancreatic carcinoma is higher than in normal pancreas tissue and pancreatic benign tumor（P〈0.05）.There was no statistically significant difference in lymphatic metastasis and tumor size between the two groups（P〉0.05）.There were statistical differences in tumor differentiated degree and local metastasis according to the degree of h-PTTG expression （P〈0.05）.Conclusions：The positive rate of h-PTTG in pancreatic carcinoma was higher than that in normal pancreatic tissue which indicated that h-PTTG participated in the tumorigenesis, development and progression of pancreatic ductal carcinoma.