小檗碱的抗菌作用研究进展

The advance on antimicrobial effect of berberine

小檗碱在临床上广泛运用于抗痢治疗,其抗菌作用被认为是其发挥抗痢作用的主要药理学机制。小檗碱的体内外抗菌活性明显,其抗菌机制可能涉及对多种酶蛋白活性抑制,肠毒素拮抗作用和抗粘附作用等机制。小檗碱的直接抗菌作用可能与其非特异性蛋白抑制作用有关。

Berberiine is clinically used in the treatment of bacterial gastrointestinal diseases such as diarrhea.Its antimicrobial activity is seen as main mechanism of anti-diarrhea in vivo.Berberine is of significant antimicrobial activity in vitro,its antimicrobial mechanism probably involved the inhabiting effect some enzyme protein,antagonistic effect on bacterial enterotoxin and anti-adhesion effect.The direct antimicrobial effect of berberine is probably related to its nonspecific inhabiting effect on protein.