KiSS-1基因产物Kisspeptins对肿瘤转移的影响

The Effect of KiSS-1 Gene on Tumor Metastasis

KiSS-1基因是从人黑色素瘤细胞中分离出的一种肿瘤转移抑制基因,能够编码多种蛋白质。研究表明,KiSS-1基因产物kisspeptins在肿瘤发生、转移、生殖系统功能的调节中发挥重要作用。KiSS-1基因作为肿瘤转移抑制基因,其表达受到极为精细的调控,并通过NF-κB介导的方式参与了对基质金属蛋白酶的转录调节,并抑制趋化因子受体CXCR4介导的信号通路,进而影响肿瘤细胞的转移能力。近年来,kisspeptins的功能及作用机制备受关注,它们可作为评价肿瘤恶性进程及预后的标志分子,并有望成为肿瘤治疗的新靶点。

KISS-1 gene, initially described as the melanoma metastasis suppressor gene, encodes a number of peptides. Recent data suggests that the products of KISS-1 play an important role in tumorgenesis and metastasis as well as in the regulation of the reproductive system. As a tumor metastasis suppressor gene, the expression of KISS-1 is precisely regulated. KISS-1 can regulate the transcription of the matrix metalloproteinase （MMPs） through the NF-κB pathway and negatively regulates chemotactic responses mediated by CXCR4. In this scenario, it is important to decipher the function and mechanism of the KISS-1 gene. KISS-1 can act as a marker to evaluate the progression of cancer. It may be used as a novel molecular target in cancer therapy.