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骨髓基质细胞移植治疗脊髓损伤的研究进展

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摘要 骨髓基质细胞(bone marrow stromal cells,BMSCs)是骨髓造血微环境的核心,其结构和功能的完整性对于保护机体造血的稳定性具有十分重要的作用。近年来的研究发现,BMSCs可分化为中胚层组织细胞.并且在一定条件下体外培养、扩增还可被诱导分化成为神经细胞样细胞和胶质细胞样细胞。动物实验显示,移植到中枢神经系统后.BMSCs能向神经细胞方向分化,使病灶的囊腔缩小,特别是在神经生长因子存在的条件下可促进轴索跨过胶质屏障生长。
作者 宋成忠
出处 《中国康复医学杂志》 CAS CSCD 北大核心 2010年第5期486-490,共5页 Chinese Journal of Rehabilitation Medicine
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  • 1张玉富,王常勇,李章华,廖文,许涛,赵强,郭希民,段翠密,郭风劲,夏仁云.组织工程技术联合早期康复治疗关节软骨缺损[J].中国康复,2004,19(3):134-136. 被引量:3
  • 2Grove JE,Bruscia E,Krause DS.Plasticity of bone marrow derived stem cells[J].Stem Cells,2004,22(4):487-500.
  • 3Lee J,Kuroda S,Shichinohe H,et al.Migration and differentiation of nuclear fluorescence-labeled bone marrow stromal cells after transplantation into cerebral infarct and spinal cord injury in mice[J].Neuropathol,2003,23 (3):169-1g0.
  • 4Deng W,Obrocka M,Fischer I,et al.In vitro differentiation of human marrow strmal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP[J].Biochem Biophys Res Commun,2001,282(1):148-152.
  • 5Long X,Olszewski M,Huang W,et al.Neural cell differentiation in vitro from adult human bone marrow mesenchymal stem cells[J].Stem Cells Dev,2005,14 (1):65-69.
  • 6Woodbury D,Schwarz EJ,Prockop DJ,et al.Adult rat and human bone marrow stromal cells differentate into neurons[J].J Neurosci Res,2000,61 (4):364-370.
  • 7Kelley MW,Turner JK,Reh TA.Retinoic acid promotes differentiation of photoreceptors in vitro[J].Develop,1994,120 (10):2091-2102.
  • 8Li M,Pevny L,Lovell-Badge R,et al.Generation of purified neural precursors from embryonic stem cells by lineage selection[J].Current Biology,1998,8(17):971-974.
  • 9Hung SC,Cheng H,Pan CY,et al.In vitro differentiation of size-sieved stem cells into electrically active neural cells[J].Stem Cells,2002,20(6):522-529.
  • 10Sofroniew MV,Howe CL,Mobley WC.Nerve growth factor signaling,neuroprotection,and neural repair[J].Annu Rev Neurosci,2001,24(3):1217-81.

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