渗出型老年性黄斑变性患者血清维生素B12和叶酸水平的检测

Serum vitamin B12 and folic acid in exudative age-related macular degeneration patients

目的 探讨血清维生素B12和叶酸的水平与渗出型老年性黄斑变性（AMD）危险因素的相互关系.方法 采用化学发光免疫分析法检测临床确诊的渗出型AMD患者84例和同期非AMD对照者78例血清维生素B12和叶酸水平.对比分析两组受检者的一般资料及高血压、糖尿病发作情况和吸烟等危险因素暴露史.结果 血清维生素B12水平检测发现,AMD组为（247.51±93.92）pg/ml,对照组为（312.52±143.08）pg/ml,二者比较,差异有统计学意义（t=5.013,P〈0.001）;血清叶酸水平检测发现,AMD组为（5.64±3.72）ng/ml,对照组为（10.14±4.48）ng/ml,二者比较,差异无统计学意义（t=0.780,P=0.437）.结论 血清维生素B12水平越低的人群发生渗出型AMD的危险性越大;叶酸与AMD危险因素无明显相关性.

Objective To investigate the serum levels of vitamin B12 and folic acid （FA） of exudative age-related macular degeneration （AMD）. Methods A total of 84 patients with exudative AMD（AMD group）and 78 patients with non-exudative AMD （control group） diagnosed at Xijing Hospital between June 2008 and September 2009 were assessed in this study. Serum vitamin B12 and FA levels were measured by chemiluminescence immunoassay. The statistical information of epidemiology and risk factors exposure histories were collected and compared. Results AMD group had significantly lower serum vitamin B12 levels[（247.51±93. 92） ng/ml]compared with the control group [（312. 52±143.08） ng/ml], the difference was statistical significance （t=5. 013, P〈0.001）. Serum FA levels in AMD group [（5. 64±3.72） ng/ml]were slightly lower than the control group [（ 10.14±4. 48） ng/ml], the difference was not statistical significance （t=0. 780, P= 0. 437）. Conclusion People with lower serum vitamin B12 have higher risk of exudative AMD. Low levels of serum vitamin B12 may relate with the occurrence of exudative AMD.