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快速免疫组化法测定C-MET蛋白预测甲状腺癌颈淋巴结转移的意义 被引量：1

Expression of C-MET in thyroid carcinoma detected by rapid immunohistochemical analysis and its clinical significance for predicting lymph node metastases
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摘要 目的探讨C-MET蛋白在甲状腺乳头状癌中的表达对甲状腺癌有无颈淋巴结转移的预测价值。方法采用术中快速免疫组化法检测85例甲状腺乳头状癌的C-MET表达,以期了解颈部淋巴结的转移情况。所有患者均行颈部淋巴结功能性清扫,比较C-MET蛋白两种染色强度的淋巴结转移率。结果染色强阳性25例,染色阳性60例。染色强阳性组淋巴结转移率明显高于染色阳性组(P<0.001)。结论 C-MET的表达是甲状腺乳头状癌是否有淋巴结转移的预测因子。术中快速免疫组化检查对决定是否行淋巴结清扫有一定的指导意义。 Objective To investigate expression of C-MET in palliary thyroid carcinoma（PTC） detected by rapid immunohistochemical analysis and its clinical significance to predicting lymph node metastases.Methods The expression level of C-MET was examined by rapid immunohistochemical analysis with C-MET-EPOS antibody in 85 cases of PTC.Results The rate of cervical lymph node metastates in PTC with strong positive stain expression（95.0%,23/25） was significantly higher than in PTC with positive stain expression（13.4%,8/60）（P〈0.001）.Conclusions Intense c-Met expression is an indicator of the presence of the cervical lymph node metastases.C-Met expression by rapid immunohistochemical analysis is a significant indicator for estimation of cervical lymph node metastates and choice of operative methods.
作者 张春旭 郭树军 王强
机构地区 解放军第一五三医院西区普通外科 上海第二军医大学长征医院普通外科
出处 《中国普通外科杂志》 CAS CSCD 北大核心 2010年第5期471-474,共4页 China Journal of General Surgery
关键词 甲状腺肿瘤 腺癌 乳头状 C-MET 颈部淋巴结转移 快速免疫组化 Thyroid Neoplasms Adenocarcinoma Papillary C-MET Cervical Lymph Node Metastases Ripid Immunohistochemical Analysis
分类号 R736.1 [医药卫生—肿瘤]
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参考文献22

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二级参考文献10

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中国普通外科杂志
2010年 第5期

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