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Exendin-4与神经退行性疾病的关系 被引量：1

Relationship between exendin-4 and neurodegenerative diseases
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摘要 Exendin-4是一种糖尿病新药,也是胰高血糖素样肽-1(GLP-1)类似物,能激活GLP-l受体,上调cAMP发挥生理活性。GLP-1受体与神经元可塑性及存活密切联系。Exendin-4还能激活多条信号通路,调节胞内钙离子(Ca2+)稳态,减轻兴奋性毒性,抑制细胞凋亡,促进神经元增生、分化,对神经退行性疾病有治疗作用。该文旨在阐明exendin-4的神经保护机制,为神经退行性疾病的预防与治疗提供新思路。 Exendin-4,a peptide analogue of glucagon-like peptide-1（GLP-1）,is presently in clinical trials as a therapy for type 2 diabetes mellitus.Exendin-4 selectively acts on GLP-1 receptors,which are coupled to the cAMP nucleotide second messenger pathway to enhance the survival and plasticity of neurons in the brain.Exendin-4 has potent effects on homeostasis of Ca2＋,on multiple targets to block apoptotic signaling pathways,and on neuronal proliferation and differentiation.It has also been demonstrated to possess properties against oxidative stress and excitotoxicity.In this review the functions of exendin-4 on central nerve system and the potentia therapeutic effects on neurodegenerative diseases will be involved.
作者 柳超 郭军
机构地区 南京医科大学基础医学实验教学中心
出处 《中国药理学通报》 CAS CSCD 北大核心 2010年第5期566-569,共4页 Chinese Pharmacological Bulletin
基金 国家自然科学基金资助项目(No30871200) 江苏省卫生厅自然科学基金资助项目(NoH200749)
关键词 EXENDIN-4 GLP-1受体 CAMP 神经退行性疾病 exendin-4 GLP-1 receptor cAMP neurodegenerative diseases
分类号 R341.6 [医药卫生—基础医学] R742.2 [医药卫生—神经病学与精神病学]
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参考文献22

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二级参考文献21

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中国药理学通报
2010年 第5期

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