摘要
目的探讨肾透明细胞癌caveolin-1的表达与临床病理学意义,同时探讨caveolin-1表达与微血管密度(MVD)的相关性。方法应用免疫组织化方法 (SP法)检测43例肾透明细胞癌caveolin-1的表达,同时通过标记CD34的表达来检测微血管密度。结果肾透明细胞癌caveolin-1表达的阳性率为67.4%(29/43),caveolin-1表达与性别和年龄无关,但是与肿块大小、临床TNM分期、病理核分级和生存时间有关(P<0.05);caveolin-1表达阳性组MVD明显高于caveolin-1表达阴性组(P<0.05)。结论 caveolin-1的表达有助于肾癌预后的评价,且caveolin-1可能参与调节肿瘤血管的形成。
Objective To investigate both the clinicopathologic significance of the expression of caveolin-1 in the renal clear cell carcinoma and the corelation between the expression of caveolin-1 and microvessel density.Methods The expression of caveolin-1 detected by immunohistochemistry method,while the microvessel density was assessed using immunohistochemistry method by marking CD34.Results In the renal clear carcinoma,the positive rate of caveolin-1 was 67.4%,the over expression of caveolin-1 was not related with gender and age,but was related with clinicopathologic parameter,such as tumor sizes,clinical TNM stage,nuclear stage and survival time（P〈0.05）.The MVD of cases with positive caveolin-1 was significantly higher than those without caveolin-1 expression（P〈0.05）.Conclusion The expresion of caveolin-1 is helpful in the prognostic evalution of renal clear cell carcinoma and it may be involved in the angiogenesis of the renal clear cell carcinoma.
出处
《肿瘤防治研究》
CAS
CSCD
北大核心
2010年第5期555-557,共3页
Cancer Research on Prevention and Treatment
基金
上海市浦东新区科技发展基金资助(PKJ2009-Y24)
