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2型糖尿病大鼠心肌脂肪酸转运体FAT/CD36的表达变化及其对脂肪酸代谢的影响 被引量：2

Change of myocardium FAT/CD36 expression in rats with type 2 diabete and its influence on fatty acid metabolism
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摘要 在心血管疾病的众多危险因素中,糖尿病日益受到人们的重视。糖尿病时高血糖、高胰岛素及血脂异常可加重冠状动脉硬化的程度,增高冠心病的发病率,同时糖尿病亦是非缺血性心力衰竭的重要病因。
作者 张治宇 倪海莱 赵彤 袁志忠 殷仁富
机构地区 第二军医大学上海军职以上退休干部休养所 第二军医大学长征医院贵宾诊疗科
出处 《第二军医大学学报》 CAS CSCD 北大核心 2010年第5期576-578,共3页 Academic Journal of Second Military Medical University
关键词 心肌 CD36抗原 2型糖尿病 脂肪酸
分类号 R587.1 [医药卫生—内分泌]
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参考文献10

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  • 2Srinivasan K, Viswanad B, Asrat L, Kaul C L, Ramarao P. Combination of high-fat diet-fed and low-dose streptozotocintreated rat: a model for type 2 diabetes and pharmacological screening[J]. Pharmacol Res, 2005,52 : 313-320.
  • 3Hajri T, Abumrad N A. Fatty acid transport across membranes: relevance to nutrition and metabolic pathology[J]. Annu Rev Nutr, 2002,22: 383-415.
  • 4Carley A N,Atkinson L L,Bonen A, Harper M E,Kunnathu S, Lopaschuk G D, et al. Mechanisms responsible for enhanced fatty acid utilization by perfused hearts from type 2 diabetic db/db mice[J]. Arch Physiol Biochem,2007,113:65-75.
  • 5Han X X, Chabowski A, Tandon N N, Calles-Escandon J, Glatz J F, Luiken J J,et al. Metabolic challenges reveal impaired fatty acid metabolism and translocation of FAT/CD36 but not FAB- Ppm in obese Zucker rat muscle[J]. Am J Physiol Endocrinol Metab, 2007,293 : E566-E575.
  • 6Cook G A,Edwards T L,Jansen M S,Bahouth S W,Wilcox H G,Park E A. Differential regulation of carnitine palmitoyltrans ferase-I gene isoforms (CPT-I alpha and CPT I beta) in the rat heart[J]. J Mol Cell Cardiol,2001,33: 317-329.
  • 7Holloway G P,Luiken J J,Glatz J F,Spriet L L,Bonen A. Contribution of FAT/CD36 to the regulation of skeletal muscle fatty acid oxidation: an overview[J].Acta Physiol (Oxf), 2008, 194 : 293-309.
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同被引文献17

  • 1陈松娥,彭峰林,邓树勋.有氧耐力训练对大鼠心脏机能和心肌脂肪酸氧化酶基因表达的影响[J].体育科学,2006,26(12):70-72. 被引量：5
  • 2Aneja A, Tang WH, Bansilal S, et al. Diabetic cardiomyopa- thy: insights into pathogenesis, diagnostic challenges, and therapeutic options. Am J Med. 2008, 121(9):748-757.
  • 3Boudina S, Abel ED. Diabetic cardiomyopathy, causes and effects. Rev Endocr Metab Disord. 2010, 11(1) :31-39.
  • 4Boudina S, Abel ED. Diabetic eardiomyopathy revisited. Cir- culation. 2007,115 (25) : 3213-3223.
  • 5Avogaro A, Vigili de Kreutzenberg S, Negut C, et al. Dia- betic cardiomyopathy: a metabolic perspective. AmJ Cardiol. 2004, 93(8A) :13A-16A.
  • 6An D, Rodrigues B. Role of changes in cardiac metabolism in development of diabetic cardiomyopathy. Am J Physiol Heart Circ Physiol. 2006, 291(4) :H1489-1506.
  • 7Barger PM, Kelly DP. PPAR signaling in the control of cardi- ac energy metabolism. Trends Cardiovasc Med. 2000, 10(6) : 238-245.
  • 8Holness MJ, Samsuddin S, Sugden MC. The role of PPARs in modulating cardiac metabolism in diabetes. Pharmacol Res. 2009, 60(3) :185-194.
  • 9Yang Q, Li Y. Roles of PPARs on regulating myocardial energy and lipid homeostasis. J Mol Med. 2007, 85(7):697-706.
  • 10Baranowski M, Blachnio-Zabielska A, Gorski J. Peroxisome proliferator-activated receptor alpha activation induces un- favourable changes in fatty acid composition of myocardial phospholipids. J Physiol Pharmacol. 2009: 60(2) : 13-20.

引证文献2

二级引证文献9

第二军医大学学报
2010年 第5期

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