肿瘤相关糖类抗原CA125、CA72-4和铁蛋白联合检测对卵巢癌的诊断价值

The Clinical Value of Combined Dectection of CA125,CA72-4 and Ferritin in Patients with Ovarian Cancer

目的评价外周血清肿瘤相关糖类抗原CA125、CA72-4和铁蛋白(Ferritin)联合测定对卵巢癌的诊断价值。方法采用电化学发光免疫分析法测定122例卵巢癌、60例良性卵巢肿瘤和50例健康体检者外周血清的CA125、CA72-4和铁蛋白(Ferritin)的水平,采用t检验和χ2检验进行数据统计分析。结果卵巢癌组CA125、CA72-4和Ferritin的水平及阳性率分别为(436.4±137.5)U/ml与72.9%、(43.2±31.5)U/ml与47.5%、(1213.5±782.6)ng/ml与53.3%,明显高于良性卵巢肿瘤组的(62.3±25.6)U/ml与18.3%、(10.4±4.8)U/ml与15.0%、(623.4±214.6)ng/ml与32.0%及健康对照组的42.5U/ml与2.0%、(8.8±3.1)U/ml与4.0%、(544.6±135.4)ng/ml与16.0%,P<0.01。随着临床分期的逐步升高,CA125、CA72-4、Ferritin阳性率和水平也不同程度升高。结论外周血清CA125、CA72-4和Ferritin联合检测可提高卵巢癌的检出率,对卵巢良性肿瘤和卵巢癌的诊断及鉴别诊断具有重要临床意义,弥补了单独检测CA125的不足。

Objective To investigate the clinic significance of serum levels of CA125, CA72-4 and Ferritin in patients with ovarian cancer. Methods The levels of CA125, CA72-4 and Ferritin in 122 patients with ovarian cancer, in 60 patients with benign ovarian tumor and in 50 healthy controls were measured by electrochemistry lumonescence immunoassay method. Statistical analyses were performed with T test and X2 test methods. Results The serum levels of CA125, CA72-4 and Ferritin in patients with ovarian cancer were （436.4±137.5） U/ml, （43.2±31.5） U/ml and （1213.5± 782.6） ng/ml, respectively, but those with benign ovarian tumor were（62.3±25.6）U/ml, （10.4±4.8） U/ml and（623.4± 214.6）ng/ml, respectively, and those healthy controls were 42.5U/ml, （8.8±3.1）U/ml and （544.6±135.4）ng/ml, respectively.The serum levels of CA125,CA72-4 and Ferritin in patients with ovarian cancer were significantly higher than those with benign ovarian tumor （P〈0.01）.Compared with healthy controls patients with benign ovarian tumor have significantly higher levels of CA125,CA72-4 and Ferritin.The positive rates of CA125, CA72-4 and Ferrtin in patients with ovarian cancer were 72.9%, 47.5%, and 53.3%, respectively, in patients with benign ovarian tumor were 18.3%, 15.0% and 32.0%, respectively and in healthy controls were 2.0%, 4.0% and 16.0%, respectively. The positive rate and levels of CA125, CA72-4 and Ferritin were increasing with the clinical stage. Conclusion Combined detection of CA125, CA72-4 and Ferritin can increase the positive detection of ovarian cancer,and thus are helpful in diagnosis of ovarian cancer and compensate the use of only one tumor marker, CA125, for the lower positive rate.