自拟调糖方对糖尿病模型小鼠血糖及胰腺病理的影响

Effects of the blood glucose-adjusting recipe on blood glucose and pancreas islet pathology in diabetic mice

目的探讨自拟调糖方对糖尿病小鼠血糖、胰腺病理的影响。方法尾静脉注射四氧嘧啶造成小鼠糖尿病模型,灌服高剂量(20g/kg)、中剂量(10g/kg)、低剂量(5g/kg)调糖方21d后,用血糖检测仪测定糖尿病小鼠空腹血糖和糖耐量的变化以及在光镜下观察胰腺、胰岛组织学变化。结果调糖方高剂量组能显著降低空腹血糖;调糖方高、中、低剂量组非常显著或显著降低灌服葡萄糖后0.5h血糖,调糖方高、中剂量组显著降低灌服葡萄糖后2h血糖。调糖方高、中剂量组能明显提高糖耐量。胰腺病理显示,调糖方能改善四氧嘧啶引起的病理损害。结论以苦瓜、黄芪、黄精、地黄等配制的调糖方具有较好地调节血糖稳定的作用。

Objective To study the effects of a self-formulated blood glucose-adjusting recipe on blood glucose and pathology of the pancreas in diabetic mice.Methods Diabetes mellitus （DM） was induced in mice by injection of alloxan through the caudal vein.The blood glucose-adjusting recipe was administered in the mice at the doses of 20,10 and 5 g/kg for 21 days,after which blood glucose was determined and the sugar tolerance was evaluated,and the pancreas and islet pathologies were examined microscopically.Results The blood glucose-adjusting recipe at 20 g/kg significantly lowered the fast blood glucose in the mice,and at 20 and 10 g/kg,the recipe significantly lowered the blood glucose 2 h after glucose administration and increased the sugar tolerance.The pathological damage in the diabetic mice was alleviated after treatment with the recipe.Conclusions The blood glucose-adjusting recipe has a good effect in stabilizing blood glucose in mice.