动脉硬化闭塞症和深静脉血栓形成患者同型半胱氨酸临床检测结果及临床意义

Measurement of Homocysteine in ASO and VT Patients through Enzymatic Cycling Assay

目的:探讨动脉硬化闭塞症(ASO)和静脉血栓形成(VT)患者同型半胱氨酸(Hcy)变化。方法:通过循环酶法对34例非动脉硬化闭塞症(ASO)和静脉血栓形成(VT)患者(对照组),30例动脉硬化闭塞症(ASO)患者和26例静脉血栓形成(VT)患者血液中Hcy进行测定。结果:循环酶法测定HCY的批内平均变异系数为2.23%,批间平均变异系数为1.59%。34例对照组,t=1.135,P=0.266>0.05;动脉硬化闭塞症(ASO)组Hcy含量明显高于对照组(P<O.05),静脉血栓形成(VT)组Hcy含量高于对照组(P<0.O5)。结论:高同型半胱氨酸血症可能是动脉硬化闭塞症(ASO)和静脉血栓形成(VT)及复发的致病因素。可将同型半胱氨酸作为动脉硬化闭塞症(ASO)和静脉血栓形成(VT)及复发的重要指标。

Objective：TO syudy the changes of the Homocysteine about Atherosclerosis obliterans and Venous thrombosis patients.Methods：To measure the Hcy in the blood of 34 healthy cases-both non ASO and non VT（the comparison group）,30 cases of ASO patients and 26 cases of VT patients respectively by enzymatic cycling assay.Results：The average variation coefficient of Hcy within the groups was 2.23% and among the groups was 1.59% measured by enzymatic cycling assay.In the 34 cases of comparison group,t=1.135,P=0.266〉0.05,The content of Hcy in the blood of ASO patients group were significantly higher than the comparision group （P〈0.05）,and the content of Hcy in the blood of VT patients group were also higher than the comparison group （P〈0.05）.Conclusion：Hyper Hcy may be the pathogenic diathesis to form or to recrudesce ASO and VT.So we can treat Hcy as the significant index to form or to recrudesce ASO and VT.