PCNA和VEGF在胃癌组织中表达的关系及意义

Expression and Significance of PCNA and VEGF in Gastric Cancer

目的:探讨PCNA,VEGF在胃癌组织中的表达关系及其意义。方法:免疫组织化学法检测正常胃和胃癌组织中PCNA和VEGF的表达,并分析其与胃癌临床病理特征的相关性。结果:胃癌组织中PCNA、VEGF的阳性表达率分别为85.0%、68.3%,二者在正常胃组织中均为隐性表达。PCNA的表达与肿瘤分期、淋巴结转移有关(P<0.05),而与年龄、性别、肿瘤大小、组织分化程度无关(P>0.05);PCNA的表达与肿瘤分期、淋巴结转移有关(P<0.05),而与年龄、性别、肿瘤大小、组织分化程度无关(P>0.05)。PCNA和VEGF在胃癌中的表达呈正相关。结论:PCNA和VEGF在胃癌组织中的高表达促进了胃癌的发生发展。

Objective：To study the significance and relationship of expression of proliferating cell nuclear antigen（PCNA） and vascular endothelial growth factor （VEGF） in gastric cancer.Methods：The expression of VEGF and PCNA in normal gastric tissues and gastric cancer tissues were detected by immunohistochemistry （SP）,and clinic pathological correlation with gastric cancer was analyzed.Results：The positive exression rates of PCNA and VEGF in gastric cancer were 85.0%、68.3%,respectively,while negative expression was shown in normal gastric tissues.It was found that the expressions of PCNA and VEGF were both in significant relation to TNM stages and lymph node metastasis （P〈0.05）,but in no relation to age,gender,diameter of tumor and tumor cell differentiation （P〉0.05）.The expressions of PCNA and VEGF were positively correlated with each other.Conclusion：It was indicated that the high-level expressions of PCNA and VEGF might corporately accelerate the progression of gastric cancer.