重度、极重度COPD急性加重期合并多器官功能障碍226例临床研究

Clinical Study of 226 Cases of Severe or Very Severe Chronic Obstructive Pulmonary Disease Exacerbation Combining with Multiple Organ Dysfunction Syndrome

目的:探讨重度、极重度COPD急性加重期合并多MODS临床特征和预后有关的危险因素。方法:回顾分析1999～2009年因重度、极重度COPD急性期合并多器官功能障碍而住院的患者临床资料。结果:本研究共纳入226例患者,平均年龄为69.3±5.2岁。呼吸系统功能障碍发生率最高,有200例。其次是心血管功能障碍和中枢神经功能障碍,各102例。患者的病死率随着器官功能障碍的数目增加而增加。结论:治疗重度、极重度COPD急性加重时,在常规治疗基础的同时防治MODS是降低患者病死率的关键。

Objective：To analyze the clinical characters and risk factors that relevant to prognosis of severe or very severe chronic obstructive pulmonary disease（COPD）exacerbation combining with multiple organ dysfunction syndrome（MODS）.Methods：The clinical data of patients who was admitted to hospital for exacerbation of severe or very severe COPD combing with MODS in 1999 to 2009 were retrospective analyzed.Results：226 cases were analyzed in this study,the mean age of patients was 69.3±5.2.The incidence of respiratory system dysfunction was highest,which was 200 cases,and followed by the incidence of cardiovascular dysfunction and central nervous system dysfunction,which was 102 respectively.The mortality of these patients increased with the increasing number of organ dysfunction.Conclusion：Prevent and te at MODS on the basis of conventional treatment of severe or very severe COPD exacerbation is the key factor that could reduce mortality of these patients.