血肌酐清除率与冠心病关系分析

The Relation of the Estimated Gomerular Filtration Rate and Coronary Artery Disease

目的:了解血肌酐清除率受损是否与冠心病患病率存在联系。方法:纳入2006年7月至2008年2月期间经冠状动脉造影证实的冠心病患者及年龄、性别匹配的对照组,按血肌酐清除率值将患者分为正常[≥90 mg/(mL·1.73m^2)],轻度受损[≥60mg/(mL·1.73m^2),<90 mg/(mL·1.73m^2)]和明显受损[<60 mg/(mL·1.73m^2)]。比较冠心病组与对照组各组人群的比例有无差异。结果:研究期间共纳入冠心病组和对照组患者各116例。在冠心病组中,血肌酐清除率正常患者82例、轻度受损29例、重度受损5例,对照组中,正常患者98例、轻度受损13例、重度受损5例,两组比较分布有统计学差异(x^2值7.517,P=0.023)。与对照组比较,冠心病组的血清肌酐值无明显差异(P>0.05),冠心病组(103.29±51.08)μmol/L,对照组(102.67±41.21)μmol/L。结论:血肌酐清除率降低是冠心病的危险因素。

Objective：To disclose the relation of the estimated glomerular filtration rate（eGFR） and coronary artery disease.Methods：We analyzed eGFR in the patients with coronary artery disease confirmed by coronary angiography and the control,and compared the proportion of patients with reduced renal function in the different groups.Results： A total 116 cases were included in each group.Among these patients,normal renal function,mildly and severe reduced renal function was documented in 82,29 and 5 in coronary artery disease group,and in 98,13 and 5 in the control group,respectively.In comparison to the control,more patients with reduced eGFR were found in coronary artery disease group（x^2 value 7.517,P = 0.023）,although no significant difference was observed between both groups （P0.05）.Conclusion：Reduced eGFR,even if mildly,could be regarded as the risk factor of coronary artery disease.