静脉及口服胺碘酮同时应用治疗充血性心力衰竭心房颤动伴快速心室率的临床分析

Efficacy United with Intravenous and Oral Amiodarone in Treatment of Atrial Fibrillation with Congestive Heart Failure

目的:探讨胺碘酮治疗充血性心力衰竭(CHF)心房颤动伴快速心室率的临床疗效。方法:将106例各种原因所致的房颤伴快速心室率的CHF患者按入院顺序随机分为治疗组及对照组。两组抗CHF基础治疗相同,治疗组加用静脉负荷量胺碘酮150 mg后,再以1000μg/min静脉点滴维持6小时,500μg/min静滴18小时。同时口服胺碘酮0.2,3次/d,1周;再0.2,2次/d,1周以后以0.2,1次/d至观察终点,随诊为12个月。结果:治疗组53例使用胺碘酮治疗可显著增加抗心律失常有效性,改善左室射血分数,减少心力衰竭再住院率,42例患者转复为室性心律。结论:静脉及口服胺碘酮同时应用治疗充血性心力衰竭房颤是有效和安全的。

Objective：To explore the effect and safety of amiodarone in the treatment of atrial fibrillation with congestive heart failure.Methods：One hundred and six patients of AF with CHF caused by a variety of reasons were randomly divided into treatment group and control group according to hospitalized order.The two groups were treated with the same anti-CHF therapy,the treatment group was treated with loaded intravenous amiodarone 150 mg;and then dripped to 1 000μg/min for 6 hours,dripped to 500μg/min for 18 hours.United with oral amiodarone by amiodarone tablets with 0.2 g,3 time/day a week,further 0.2 g,2 times/day a week,later 0.2 g,1 times/day to the end.The end of follow-up time was 12 months.Results：In treatment group,53 cases with amiodarone therapy can significantly increase the effectives of anti-arrhythmic,improve the rate and heart failure rehospitalization.42/53 patients reversed to sinus rhythm.Conclusion：The results showed it is effective and safe united with intravenous amiodarone and oral amiodarone in treatment of atrial fibrillation with organic heart disease.