摘要
目的:检测枝孢样枝孢霉对5种常用抗真菌药物的敏感性,为治疗枝孢样枝孢霉感染提供抗真菌药物的参考依据。方法:微量稀释法进行最小抑菌浓度(MIC)测定,所选菌悬液终浓度为(0.4~5)×106cfu/mL.孵育温度35℃,培养时间5~7d。测定枝孢样枝孢霉对氟康唑、伊曲康唑、联苯苄唑、益康唑、制霉菌素的最小抑菌浓度(MIC)。结果:枝孢样枝孢霉除了对氟康唑敏感性较差外,对其它4种抗真菌药物敏感性均较高。结论:检测枝孢样枝孢霉对抗真菌药物的敏感性是必要的和有价值的,但体外试验仅可作为体内治疗选药的参考。
objective: Investigate the antifungal susceptibility characteristic to know ifCladosporium cladosporioides is sensitive to common antifungal drugs. Method: The media containing the fungi in the concentrations of(0.4-5) × 10^6cfu/mL were incubated at 35℃ for 5-7days. Result: The tested Cladosporium cladosporioides were highly susceptible to itraconazole, bifonazole, econazole and nystatin, but it's poorly susceptible to fluconazol. Conclusion: it is necessary to monitor the resistant strains in antifungal treatment.
关键词
枝孢样枝孢霉
抗真菌药物
药敏性实验
Cladosporium Cladosporioides
Antifungal
Microbial Sensitivity Tests