摘要
糖尿病是以高血糖为代谢特征的严重影响人类健康的疾病。目前,糖尿病较理想的治疗方法是胰腺移植,但受供体缺乏和免疫排斥两方面的限制而不能普遍应用。干细胞由于具有自我更新和多分化潜能,其作为糖尿病细胞替代治疗的种子资源,已成为目前研究的热点。本文对近年来干细胞分化为胰岛细胞的研究进展作一综述。
Diabetes mellitus（DM）with an characteristic of hyperglycemia is a common disease which affect the health of humans.At present,islet transplantation is an ideal cure for DM.However,donor scarcity and graft versus host reaction are the main hurdles for islet transplantation.Stem cell with the feature of self-renew and multiple potent differentiation is a proper seed resource for islet-transplantation therapy,which has become a focus of study on treatment of DM.This paper reviews the progress in research on differentiation of stem cells to island cells in recent years.
出处
《中国生物制品学杂志》
CAS
CSCD
2010年第5期539-543,共5页
Chinese Journal of Biologicals
关键词
糖尿病
干细胞
分化
胰岛细胞
Diabetes mellitus（DM）
Stem cells
Differentiation
Island cells
