摘要
早期形态和胚胎学研究结果表明,文昌鱼哈氏窝、内柱和肝盲囊分别是脊椎动物脑垂体、甲状腺和肝脏的同源器官。文章总结了近年来有关文昌鱼肝盲囊与脊椎动物肝脏之间关系的研究成果,揭示文昌鱼肝盲囊和脊椎动物肝脏具有同源性,并证明文昌鱼中存在类似脊椎动物的GH/IGF(Growth horm one/insulin-like growth factor)和TH/THR(Thyroid horm one/thyroid horm one receptor)信号通路,为脊椎动物肝脏起源于文昌鱼肝盲囊样结构提供了分子水平证据。
Previous studies on morphology and embryology revealed that the Hatschek＇s pit,endostyle and hepatic caecum in amphioxus were homologous to the precursors of pituitary,thyroid and liver in vertebrates,respectively.Here,we summarize the recent advances on the relationship between amphioxus hepatic caecum and the vertebrate liver as well as the origin of growth hormone/insulin-like growth factor（GH/IGF） and thyroid hormone/thyroid hormone receptor（TH/THR） signal pathways,which will provide molecular support to the homology of amphioxus hepatic caecum to vertebrate liver.
出处
《遗传》
CAS
CSCD
北大核心
2010年第5期437-442,共6页
Hereditas（Beijing)
基金
国家自然科学基金项目(编号:39770091
30470203
30070110)资助
