逆行面动脉为蒂的下颌下腺移植的实验研究

Transplantation of a reverse facial artery pedicled submandibular gland in a dog

目的:探讨用逆行面动脉为蒂的下颌下腺移植治疗角结膜干燥症的可能性。方法:利用逆行面动脉为蒂的自体下颌下腺(包括导管)移植到实验用Beagle犬的颞部。99mTc核素扫描监测移植的下颌下腺的活力,并且在移植12周后对移植物进行组织学检查。结果:术后99mTc核素扫描证实在移植区域有存活的唾液腺。组织学检查发现,移植的下颌下腺部分腺泡细胞发生了萎缩。结论:逆行面动脉为蒂的下颌下腺移植治疗角结膜干燥症是一种适合和安全的治疗方法。

PURPOSE： To evaluate the possibility of using reverse facial artery pedicled submandibular gland transfer for treating keratoconjunctivitis sicca.METHODS： A reverse facial artery pedicled submandibular gland,including the duct,from a Beagle dog was transplanted into the temporal region in the same animal.99mTc pertechnetate scintigraphy was used to monitor the graft viability,and the grafted glands were examined histologically 12 weeks after transplantation.RESULTS： Postoperative 99mTc pertechnetate scintigraphy demonstrated viable salivary gland tissue in the transplanted region.Histologically,some of the acinar cells in the graft had atrophied.CONCLUSIONS： The transplantation of a reverse facial artery pedicled submandibular gland was successful and may be a simple,reliable treatment for patients with keratoconjunctivitis sicca.