Notch信号对血管新生调控作用的研究进展

Research advance in Notch signals in modulation of angiogenesis

对Notch信号在血管新生中作用的研究主要集中于内皮细胞的增生、尖细胞与茎细胞比例调节、动静脉分化及周细胞动员等方面。Notch调控血管生成的研究可为组织缺血、创伤和肿瘤等提供合理的治疗方向。该文就Notch信号转导通路的组成、Notch在生理性血管新生中的作用和机制,以及在脐血造血干细胞中的应用研究作一综述。

The research in roles of Notch signals in angiogenesis mainly concentrates on endothelial cell proliferation,regulation of ratio of tip cells to stalk cells,arterial-venous differentiation and perithelial cell mobilization.The research on Notch signals in angiogenesis may enable us to launch rational treatment targeting tissue ischemia,trauma and tumors.The composition of Notch signaling,roles and mechanism of Notch in physiological angiogenesis and application research on cord blood hematopoietic stem cells are reviewed in this paper.