酒石酸拉索昔芬合成路线图解
被引量：2
Graphical Synthetic Routes of Lasofoxifene Tartrate
摘要
酒石酸拉索昔芬（lasofoxifenetartrate，1），化学名为（5R，6S）-5,6，7，8-四氢-6-苯基-5-[4-[2-（1-吡咯烷基）乙氧基]苯基]-2-萘酚（2S，3S）-酒石酸盐，是美国辉瑞公司研发的选择性雌激素受体调节剂，2009年4月在欧洲批准上市，
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2010年第6期468-471,共4页
Chinese Journal of Pharmaceuticals
参考文献25
-
1马培奇.拉索昔芬及其研究进展[J].中国制药信息,2006,22(5):15-16. 被引量：2
-
2Daniel L.Alkoxy-substituted 2-phenyl-1-(tertiaryaminoalkoxy) phenyl 3,4-dihydronaphthalenes:US,3274213[P].1966-09-20.(CA 1966,66:2416).
-
3Hino K,Nagai Y,Uno H,et al.A novel class of potential central nervous system agents.3-Phenyl-2-(1-piperazinyl)-5H-1-benzazepines[J].J Med Chem,1988,31 (1):107-117.
-
4卡莫罗KO,杰里迪PAD,罗萨迪RL.雌激素激动剂/拮抗剂:中国,1059902[P].2000-12-27.(CA 1996,125:195446).
-
5Lustig P,Hejtmankova L.Method for the preparation of lasofoxifene:WO,2008145075[P].2008-05-28.(CA2008,150:19991).
-
6Lednicer D,Lyster SC,Aspergren BD,et al.Mammalian antifcrtility agents.3.1-Aryl-2-phenyl-1,2,3,4-tetrahydrolnaphthols,1-aryl-2-phenyl-3,4-dihydronaphthalenes,and their derivatives[J].J Med Chem,1966,9 (2):172-176.
-
7Hobbs-Mallyon D,Li W,Whiting DA.Aryltricyclospirodie nones novel steroid mimics as inhibitors of aromatase[J].J Chem Soc Perkin Tram I,1997:1511-1516.
-
8Adkins H,Krsek G.Comparison of nickel catalysts in the hydrogenation of β-naphthol[J].J Am Chem Soc,1948,70(1):412.
-
9Mallory FB,Rudolph MJ,Oh SM.Photochemistry of stilbenes.8.Eliminative photocyclization of o-methoxystilbcnes[J].J Org Chem,1989,54 (19):4619-4626.
-
10Hou Y,Higashiya S,Fuchigami T.Electrolytic partial fluorination of organic compounds.Highly regioselective anodic monofluorination of oxindole and 3-oxo-1,2,3,4-tetrahydro isoquinoline derivatives:effects of supporting fluoride salts and anode materials[J].J Org Chem,1997,62 (25):8767-8772.
同被引文献18
-
1童玲,朱雪焱,袁哲东.酒石酸拉索昔芬的合成[J].中国医药工业杂志,2011,42(7):481-483. 被引量：1
-
2王蔚,艾敏.治疗骨质疏松症的新药Lasofoxifene[J].药学进展,2005,29(2). 被引量：1
-
3马培奇.拉索昔芬及其研究进展[J].中国制药信息,2006,22(5):15-16. 被引量：2
-
4Elhalem E, Bailey B N, Docampo R, et al. Design, synthe- sis, and biological evaluation of aryloxyethyl thiocyanate derivatives against trypanosoma cruzi [ J ]. J Med Chem,2002,45(18) :3984-3999.
-
5Meegan M J, Hughes R B, Lloyd D G, et al. Flexible estro- gen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells [ J ]. J Med Chem ,2001, 44 ( 7 ) :1072-1084.
-
6Schickander H, Roland I. Erythro-1,2-1-pentanones [ P ]. US:4764533,1988-08-16.
-
7Cameron KO,Jardine PA,Rosati RL.5-Substituted 6-cy-clic-5,6,7,8-tetrahydronaphthalen-2-ol compounds which are useful for treating osteoporosis:US,005552412 [P].1996-07-03.
-
8Lednicer D,Township P,County K,et al.Alkoxy-substituted 2-phenyl-1-(tertiary-aminoalkoxy)phenyl-3,4-dihydronaph-thalenes:US,3274213 [P].1966-07-20.
-
9Ivana GS,Carin S,Colacot TJ.The process for the prepara-tion of a-substituted ketones and their application in synthe-sis of pharmaceutically active compounds:WO,2012159981 [P].2012-11-29.
-
10Sherry BD,Furstner A.The promise and challenge of iron-catalyzed cross coupling [J].Acc Chem Res,2008,41(11):1500-1511.
引证文献2
-
1李高伟,王晓娟,赵文献,郭保国.2-苯基-1-(4-(1-吡咯乙氧基)苯基)乙酮的合成[J].化学研究与应用,2012,24(6):936-939. 被引量：2
-
2陈韵翔,黄杨威,赵学清,李忠铭.萘福昔定的合成[J].中国医药工业杂志,2014,45(6):501-503.
二级引证文献2
-
1王晓娟,李高伟,刘澜涛,郭保国,刘瑛,赵文献.手性砌块3-(S)-氨基四氢呋喃合成研究[J].化学研究与应用,2014,26(4):552-555.
-
2李修刚,张玲钰,杨航周,黄启鹏.β-芳氧基乙醇的合成方法改进研究[J].化学研究与应用,2017,29(10):1605-1608.
-
1马革委.鲎试剂法检测注射用兰索拉唑的细菌内毒素[J].北方药学,2015,12(6):99-100. 被引量：1
-
2马培奇.拉索昔芬及其研究进展[J].中国制药信息,2006,22(5):15-16. 被引量：2
-
3拉索昔芬及其研究进展[J].中国医药技术与市场,2006,6(1):67-67.
-
4张恺,薛娜,杜玉民,苏信杰,周付刚.(S)-(-)-氨磺必利-D-(-)-酒石酸盐的合成[J].中国现代应用药学,2009,26(8):635-637. 被引量：5
-
5许松山,姜万春,刘文生,王家健.2－萘酚对小鼠免疫功能影响的实验研究[J].工业卫生与职业病,1995,21(2):89-91. 被引量：4
-
6欧洲批准酒石酸拉索昔芬薄膜包衣片上市[J].世界临床药物,2009,30(6):382-382.
-
7陈韵翔,黄杨威,赵学清,李忠铭.萘福昔定的合成[J].中国医药工业杂志,2014,45(6):501-503.
-
8梁年康,卢家雯,黄伟平.2013年我院口服质子泵抑制剂的临床用药分析[J].北方药学,2015,12(4):173-173. 被引量：2
-
9李娅萍,胡昌勤,谢元超,姜雄平,魏立平,武向峰.头孢氨苄、头孢拉定原料中残留2-萘酚的控制[J].药物分析杂志,2012,32(4):555-565. 被引量：6
-
10抗肿瘤药、抗癌药物[J].国外科技资料目录（医药卫生）,2002(12):198-198.
