区域动脉灌注治疗重症急性胰腺炎的临床研究

Local Arterial Infusion of Medicine in the Treatment of Severe Acute Pancreatitis

[目的]探讨区域动脉灌注给药在重症急性胰腺炎（SAP）治疗中的作用.[方法]回顾性分析本院2002年2月至2009年6月收治的SAP患者68例的临床资料,按不同阶段的治疗方法分两组：A组（对照组）2002年2月至2007年1月共43例,按常规治疗.B组（治疗组）2007年2月至2009年6月共25例,除常规治疗外,还采用持续性区域动脉灌注（LAI）治疗,比较两组疗效.[结果]治疗组血、尿、淀粉酶下降较对照组迅速（P〈0.05）,胃肠减压量与对照组比较减少显著（P〈0.01）,并发症少,病死率低（P〈0.05）.[结论]区域动脉灌注治疗SAP疗效显著,优于常规治疗.

[Objective]To evaluate the effect of local arterial infusion （LAD of medicine on severe acute pancreatitis （SAP）. [Methods] The clinical data of 68 case of SAP were retrospectively analyzed, and divided into two groups. Group A （control group, n ：43） admitted from February 2002 to January 2007 received only the routine therapy and Group B （treatment group, n = 25） admitted from February 2007 to June 2009 received LAI therapy in addition to the routine therapy. The curative effects of the two groups were compared. [Results]The amylase in blood and urine reduced more quickly in the treatment group than in control group. The gastrointestinal decompression was significantly different between the two groups（ P 〈0.01）. Compared to group A, the mortality and morbidity in group B were statistically reduced.