多发性骨髓瘤患者血清IL-6、TNF-α的表达及临床意义

Expression of Inflammatory Cytokines IL-6 and TNF-α in Multiple Myeloma Patients and Its Clinical Significance

[目的]探讨多发性骨髓瘤（MM）患者血清炎症因子IL-6、TNF-α的表达及临床意义.[方法]2001年8月至2008年11月本院住院和门诊收治的150例MM患者为治疗组,患者入院治疗当天抽静脉血,选择年龄、性别匹配的健康体检者50例为对照组,采用放射免疫法检测血清IL-6和TNF-α.观察比较治疗组与对照组,治疗后有效组与无效组的IL-6、TNF-α的表达水平,并对其进行相关性分析.[结果]MM患者的血清IL-6、TNF-α水平随临床分期增加,其表达水平依次增高,且与对照组比较,差异有显著性（P〈0.01）;治疗有效组治疗前后IL-6,TNF-α表达水平显著下降（P〈0.01）,无效组则无差异（P〉0.05）;MM患者血清中IL-6与TNF-α呈正相关（γ=0.732,P〈0.01）.[结论]血清炎症因子IL-6、TNF-α在MM 的发生、发展中起重要的作用,可用于MM患者的病情判断和疗效监测.

[Objective]To investigate the expression of serum inflammatory cytokines interleukin-6（IL-6） and tumor necrosis factor-alpha（TNF-α） in multiple myeloma（MM） patients and its clinical significance. [Methods] A total of 150 MM patients admitted from Aug. 2001 to Nov. were enrolled in this study. Radioimmunoassay was used to detect the expression of serum IL-6 and TNF-α. The expression of serum IL-6 and TNF-α was compared between two groups, and their relationship was analyzed. [Results]Serum IL-6 and TNF-α levels in MM patients increased with the increment of the clinical stage, and there was significant difference between MM group and control group（ P 〈0.01）. Serum IL-6 in MM patients was positively corre- lated with serum TNF-α（r = 0. 732, P 〈0.01）. [Conclusion] Serum inflammatory cytokines IL-6 and TNF-α play an important role in occurrence and development of MM, and can be used to determine the condition of patients with MM and efficacy monitoring.