VEGF、LN—R在卵巢癌中的表达及临床意义

Expression of VEGF and LN-R in Ovarian Cancer and Its Clinical Significance

[目的]探讨血管内皮生长因子（VEGF）和层粘连蛋白受体（LN-R）在卵巢癌发生、发展中的作用和临床意义.[方法]用免疫组织化学SP法检测42例卵巢癌中VEGF和LN-R的表达,分析其表达与病理类型、组织学分级、FIGO分期有无转移的关系.[结果]①VEGF在卵巢癌中高水平表达78.6%（33/42）; LN-R在卵巢癌中高水平表达83.3%（35/42）.②卵巢癌临床分期越晚、组织学分化越差,伴有淋巴结或大网膜转移的卵巢癌中VEGF和LN-R的阳性表达率越高（P〈0.05）.③VEGF阳性表达与LN-R阳性表达表现出相关性（P〈0.05）.[结论]VEGF和LN-R在卵巢癌的发生和发展中呈协同一致的作用, VEGF和LN-R的阳性表达率与临床分期及组织学分级和有无转移有关,与病理类型无关,这为卵巢癌的诊断和治疗提供了依据.

[Objective] To explore the role ＇and clinical significance of vascular endothelial growth factor （VEGF） and laminin receptor（LN-R） in the occurrence and development of ovarian cancer. [Methods]The expression of VEGF and LN-R in 42 cases with ovarian cancer was detected by using immunohistochemical SP method. The relationship between the expression of VEGF or LN-R and histological type, histological grade, FIGO stage and metastasis was analyzed. [Results]The expression of VEGF and LN-R was high in ovarian cancer. The later the clinical stage of ovarian cancer, the worse the histological differentiation, and the higher the positive expression of VEGF and LN-R in ovarian cancer with lymph node and omentum majus metastasis （ P 〈0.05）. The positive expression of VEGF was related with the positive expression of LN-R（ P 〈0.05）. [Conclusion]VEGF and LN R have the synergetic effect in the occurrence and development of ovarian cancer. The positive expression rate of VEGF and LN-R is related with the clinical stage, histological grading and metastasis, which provides a basis for the diagnosis and treatment of ovarian cancer.