血液吸附治疗维持性血液透析病人皮肤瘙痒的疗效观察

Observation on therapeutic effect of resin adsorption to treat itch of skin for patients accepting maintenance hemodialysis

[目的]观察血液吸附治疗维持性血液透析病人皮肤瘙痒的疗效。[方法]选择26例重度皮肤瘙痒维持性血液透析病人随机分为观察组和对照组,每组13例,均进行2周的基础治疗后,观察组进行血液吸附联合血液透析治疗,对照组进行普通血液透析治疗,观察并比较两组病人的治疗效果,包括皮肤瘙痒程度、免疫活性甲状旁腺素(iPTH)水平、甲状旁腺素(PTH)清除率、尿素清除指数(Kt/V)。[结果]与对照组比较,观察组皮肤瘙痒程度明显缓解(P<0.05);观察组iPTH水平明显低于对照组(P<0.05);观察组PTH清除率明显高于对照组。[结论]血液吸附能有效清除PTH,缓解维持性血液透析病人皮肤瘙痒症状。

Objective： To observe the therapeutic effect of resin adsorption to treat itch of skin for patients accepting maintenance hemodialysis. Methods： A total 26 patients accepting maintenance hemodialysis with severe itch of skin were selected and randomly divided into observation group and control group13 cases each. After 2 weeks＇ basic treatment, patients in observation group received resin adsorption treatment combined with hemodialysis. And patients of control group were accepted regular hemodialysis. Therapeutic effect of two groups cases were observed and compared, which including the degree of skin itching, the level of immuno-active parathormone, clearance of parathormone, and urea clearance index. Results; Compared to control group cases, the degree of skin itching of observation group were remarkably less than that of control group （P〈0. 05）. The level of immuno--active parathormone was lower than that of control group cases （P〈0. 05）. However, the ciearance of parathormone was higher than that of control group cases （P〈0.05）. Conclusion. Resin adsorption can effectively eliminate parathormone and relieve the itch of skin for patients accepting maintenance hemodialysis.