冠心病患者血清纤维蛋白原、高敏C反应蛋白与粥样斑块不稳定性的关系研究

Clinical characteristics of the correlation between serum high-sensitivity C reactive protein,fibrinogen levels and atheromatous plaque unstability of coronary artery

目的:通过检测健康对照组及冠心病患者群血清纤维蛋白原(FIB)及炎性因子高敏C反应蛋白(hs-CRP)水平,探讨冠心病患者凝血功能紊乱、炎性因子表达与动脉粥样硬化斑块不稳定性的关系。方法:2007年10月～2008年8月于本院心内科行冠脉造影或冠脉CT患者195例,入院前均未行调脂治疗。按冠脉造影或冠脉CT结果分为健康对照组45例,冠心病患者150例,其中急性冠脉综合征(ACS)109例。入院当时检测血清脂蛋白、FIB、单核细胞趋化蛋白-1(MCP-1)、高敏C反应蛋白(hs-CRP)水平。结果:冠心病患者FIB,血清炎性因子MCP-1、hs-CRP、LDL-C水平明显升高(P<0.05),差异有统计学意义,表明患者存在炎性反应、脂代谢和凝血功能紊乱。与稳定型冠心病患者相比,ACS患者hs-CRP、FIB水平升高,差异有统计学意义,hs-CRP水平与FIB正相关,表明二者可能主要与动脉粥样硬化斑块的不稳定性相关。结论:急性冠脉综合征患者血清hs-CRP、FIB较稳定型冠心病患者明显升高,表明hs-CRP、FIB水平与冠状动脉斑块的不稳定性相关,对冠心病患者进行上述指标的检测有利于判断病情,尽早治疗,以改善预后。

Objective ：To investigate serum high-sensitivity C reactive protein （hs-CRP,fibrinogen（FIB） levels in patients with acute coronary syndrome （ACS） and steady coronary heart disease （SCHD） and their correlations with atheromatous plaque unstability of coronary artery, nethods：195 pateins were divided into two groups according to coronary artery an- giography （CAG） from October 2007 to August 2008, 150 cases with CHD and 45 cases with normal coronary angiograms （no-CHD group）, 109 patients with ACS among them, 41 pateints with SCHD. Serum HDL-C,MCP-1 and fibrinogen levels were measured at once coming into the hospital. Results： Serum LDL-C,HDL-C were significantly higher and lower in the CHD groups than in no-CHD groups. In pateints with ACS, serum hs-CRP, FIB were significantly higher than pateints with SCHD. Conclusion：The results indicate that hs-CRP,FIB are positively correlate with the atheromatous plaque unstability of coronary artery in pateints with ACS.