658份药品不良反应报告分析

Data analysis of 658 case reports on adverse drug reactions

目的分析我院2005年1月-2009年12月收到的药品不良反应(ADR)报告,旨在提高ADR监测和临床合理用药水平。方法采用回顾性分类统计,对658份ADR报告就患者年龄与性别分布,用药途径,药品类别,累及的器官、系统以及临床表现进行统计评价。结果 658份ADR报告涉及16个品种,其中,由抗感染药物引起的占326起(46.24%),居首位;临床表现以皮肤损害最多,有369起(56.08%);重度ADR28起(4.26%)。结论 ADR的发生率与患者的年龄、用药途径和频率密切相关,应加强严重ADR的监测工作。

Objective Through the analysis of 658 case reports on adverse drug reactions（ADR） collected by our hospital from 2005 to 2009 to aim the improvement of ADR monitor and drugs rational use.Methods Analyze 658 reports by retrospective classification statistic including age,sex,route of administration,drugs and their classification,organs,systems and clinical manifestations involved by ADR.Results In 16 categories of drugs involved in totally 658 reports the anti-infective agents（326 cases） was the top one.The major clinical manifestation of ADR was skin damage（369 cases）.Twenty-eight cases（4.26%） were severe ADR.Conclusion The occurrence rate of ADR is closely related to patien＇s age,route and frequency of administration.