放疗后药物灌注并加温治疗低位直肠癌的研究

Study of therapeutical effect of drug perfusion at post-radiotherapy and hyperthermia on low rectal carcinoma

目的：探讨低位直肠癌综合治疗方法，减少局部并发症，提高生存质量。方法：采用外照射，近距离后装治疗，药物保留灌注并腔内外微波加温综合治疗低位直肠癌３０例。结果：本组病例４年随访期间，４例局部复发，５例远处转移，４年生存率和无瘤生存率分别为８７％（２６／３０例）和８３％（２５／３０例）。结论：低位直肠癌的保守治疗，可通过单项减量，综合治疗，降低局部并发症和复发率。

Objective:To investigate the therapeutical effect of reserving anus in the patients of low rectal carcinoma,reducing complication and increasing survival rate.Methods:The treatments included extrasomatic radiotherapy near by tumor,intracavity and extracavity miccowave diathermy,drug perfusion .All the 30 patients were treated.Results:During the 4- years follow-up it showed that 4 cases had local recurrence and 5 cases had distant metastasis.The 4-years survival rate and tumor-free survival rate were 86.7%(26/30) and 83% (25/30 ).Conclusion:With general treatment and low dose radiotherapy,the therapeutics of reserving anus in low rectal carcinoma may increase survival quality,reduce complication and recurrence rate.