耳炎宁配伍体外协同抗菌作用的研究

Study on synergism antibacterial action of Eryanning in vitro

目的观察耳炎宁体外协同抗菌作用。方法分别检测耳炎宁1号(主要成分大黄)和2号(主要成分黄芩、黄柏等组成)的抗厌氧菌、需氧菌作用以及2者配伍后的抗菌作用。结果 1号抗厌氧菌明显,2号抗需氧菌强,2者配伍具有抗厌氧菌和抗需氧菌双重作用,对脆弱类杆菌与大肠杆菌FIC指数分别为83%和82%,对绿脓杆菌为54%。结论耳炎宁1号和耳炎宁2号配伍具有抗厌氧菌和需氧菌双重作用。

Objective It is to observe the synergism antibacterial action of Eryanning in vitro.Methods The independent action and synthetic action of Eryanning I（essential component rhubarb） and Eryanning II（essential component scutellaria,phellodendron bark,etc.） on anti-anaerobian and anti-aerobian were detected.Results Eryanning I had good action in anti-anaerobian,Eranning II had good action in anti-aerobia.The synthetic action of Eryanning I and Eryanning II was diphasic in anti-anaerobian and anti-aerobia.The fractional inhibitory concentration index on bacteroides fragilis,bacillus coli and aeruginosus bacillus were 83%,82% and 54% respectively.Conclusion Eryanning I combine with Eryanning II synthetic has diphasic action in anti-anaerobian and anti-aerobia.