术竭异位安胶囊治疗兔子宫内膜异位症的实验研究

Experimental Research on Shujie Yiweian Capsule Against Endometriosis in Rabbits

目的观察术竭异位安胶囊对兔子宫内膜异位症的治疗作用。方法手术移植法制备兔子宫内膜异位症模型,分为术竭异位安胶囊低、中、高剂量组(分别为1.9,3.8,7.6g.kg-1),灌胃给药4周。观察异位内膜外观,异位灶生长情况,进行组织形态学检查;放射免疫法测定血清中雌二醇(E2)、孕酮(P)、6-酮-前列环素(6-k-PG)、血栓素B2(TXB2)的含量。结果术竭异位安胶囊各剂量组均能使异位内膜包块积液量明显减少,体积变小,生长受到抑制,异位内膜呈萎缩相,内膜变薄,表面上皮变矮,未增生形成腺体,间质细胞小而稀疏;高、中剂量组能显著降低子宫内膜异位症兔的血清E2、P、6-k-PG和TXB2水平。结论术竭异位安胶囊对异位内膜具有明显抑制作用,可通过调节激素水平而促使异位内膜萎缩。

Objective To explore the therapeutic effect of shujie yiweian capsule on endometriosis. Methods The rabbit model of endometriosis was established by transplantation. The mode rabbits were i.g. shujie yiweian capsule 1.9,3.8,7.6 g·kg-1 for 4 weeks as low,middle and high dose. The appearance and growth of endometrium were observed and detected by histomorphological analysis; contents of estradiol（E2）,gestagen （P）,6-k-PG,TXB2 were measured by radioimmuno assay. Results It was showed that the quantity of liquid in ectopic endometrial tissue was decreased and the growth was inhibited. The ectopic endomembrane was shrunk,epithelium was thinner,no glandular organ was formed,the mesenchymal cells were small and sparse after the treatment of different doses of shujie yiweian capsules. The serum levels of E2、P、6-k-PG and TXB2 were decreased in the high and middle doses of shujie yiweian capsules treated rabbits. Conclusion Shujie yiweian capsule can holdback the growth of ectopic endometrium by decreasing hormone levels.