2[1]Chisari FV. Hepatitis B virus immunopathogenesis[J]. Annu Rev Immunol, 1995, 13: 29-61.
3[2]Chu RS, Targoni OS, Ktieg AM, et al. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1(Th1) immunity[J]. J Exp Med, 1997, 186(10): 1623-1631.
4[3]Davis HL, Weeranta R, Waldschmidt TJ, et al. CpG DNA is a potent enhancer of specific immunity in mice immunized with hepatitis B surface antigen[J]. J Immunol, 1998, 160: 870-876.
5[4]Krieg AM, Yi AK, Matson S, et al. CpG motifs in bacterial DNA trigger direct B-cell activation [J]. Nature, 1995, 374 (6522): 546-549.
6[5]Wang B, Ugen KE, Strikantan V, et al. Gene inoculation gener ates human immunodeficiency virus type 1 [J]. Proc Natl Acad Sci USA, 1993, 90: 4156-416.
7[6]Manici M, Hadchouel M, Davis HL, et al. DNA-mediated immunization in a transgenic mouse model of the hepatitis B surface antigen chronic carrier state[J]. Proc Nail Acad Sci USA, 1996, 93: 12496-12501.
8[9]Porter KR, Kochel TJ, Raviprakask K, et al. Protective efficacy of CpG immunostimulatory motifs on antibody responses[J]. Arch Virol, 1998, 143(5): 997-1003.
9[10]Sato Y, Roman M, Tighe H. et al. Immunostimulatory DNA sequences for effective intxadermal gene immunization[J]. Science, 1996, 273: 352-354.
