摘要
用分子连接性指数法对一系列喹诺酮类化合物抗结核病分支杆菌的定量构效关系进行了研究。设计了4个新的化合物,预测它们具有高的抗菌活性。
The quantitative structure activity relationship(QSAR) of the quinolone antibacterials against mycobacteria was studied by the method of molecular connectivity. Four compounds were designed, which were expected to have high antibacterial activity against Mycobacterium fortuitum .
出处
《中国药科大学学报》
CAS
CSCD
北大核心
1999年第1期16-18,共3页
Journal of China Pharmaceutical University
基金
国家自然科学基金
关键词
喹诺酮
分支杆菌
分子连接性
定量构效关系
Quinolone
Mycobacterium fortuitum
Molecular connectivity
Quantitative structure activity relationship(QSAR)