绞股蓝多糖对免疫功能的影响

Effects of Gynostemma pentaphyllum Makino Polysaccharide (PGP) on Immune Function

绞股蓝多糖（２５，５０１００ｍｇ／ｋｇ，ｉｐ）能明显提高小鼠碳粒廓清速率，其Ｋ值分别为０．０５１７±０．０１１７，０．０４１９±０．０１１９，０．０５７６±０．０４８，与对照组（ＮＳ）０．０１６９±０．０１１７相比有显著差异（Ｐ＜０．０５）。能增强肝癌Ｈｅｐｓ小鼠ＮＫ细胞活性，其活性（％）分别为２１．４０±４．００，４１．１９±１１．５６，４９．６５±５．０６，除２５ｍｇ／ｋｇ剂量组外，均显著高于对照组１７．９９±２．３５（Ｐ＜０．０５），而对肉瘤Ｓ１８０小鼠ＮＫ细胞活性无明显影响。另外对小鼠血清溶血素和Ｓ１８０小鼠脾指数有显著提高作用，但对Ｈｅｐｓ小鼠脾和胸腺指数、Ｓ１８０小鼠胸腺指数和脾淋巴细胞转化无显著作用。

PGP(25,50,100 mg/kg.ip) could markedly enhance the clearance of charcoal particles ( P <0.05), increase the NK cell activity in Heps bearing mouse except the group of 25 mg/kg ( P <0.05), but it could not markedly increase the NK cell activity in S 180 bearing mouse. PGP could significantly increase the spleen index of S 180 bearing mouse,and the level of serum hemolysin, but it had no marked effect on the index (spleen, thymus) of Heps-bearing mouse, the thymus index of S 180 bearing mouse and the lymphycyte transfermation.