摘要
本工作在整体大鼠、离体大鼠心脏与血管和培养大鼠血管平滑肌细胞（ＶＳＭＣ）上观察和比较了肾上腺髓质素前体（ｐｒｏＡｄｍ）四个不同肽段的心血管效应。肾上腺髓质素（Ａｄｍ）ｐｒｏＡｄｍＮ端２０肽（ＰＡＭＰ）和ｐｒｏＡｄｍ４５－９２肽均可以舒张大鼠主动脉环、降低血压，而肾上腺升压肽（Ａｄｔ）则收缩大鼠主动脉环。ｐｒｏＡｄｍ的四个肽段对大鼠心脏均无明显变时性和变力性作用。Ａｄｔ可以刺激大鼠ＶＳＭＣ的增殖，Ａｄｍ和ＰＡＭＰ则拮抗Ａｄｔ的促ＶＳＭＣ增殖效应。
The effects of four peptides
derived from human proadrenomedullin (pro Adm)on cardiovascularsystem were observed on
anaesthetic rats,isolated rat hearts,perfused rat aortic rings and culturesrat vascular smooth
muscle cells (VSM).It was discovered that adrenomedullin(Adm),proadrenomedullin
NH2-terminal 20 peptide(PAMP)and proAdm45-92 dilated aortic ring and decreasedblood
pressure,while adenotensin(Adt)contracted aorta.All of these peptides seemed to have
noapparent effect on isolated heart.Adt could stimulate the proliferation of
VSMC,however,bothAdm and PAMP inhibited Adt-stimulated cell proliferation.
出处
《基础医学与临床》
CSCD
1999年第1期33-37,共5页
Basic and Clinical Medicine
关键词
肾上腺髓质素
前体
肽段
心血管效应
proadrenomedullin adrenomedullin proadrenomedullin NH2-terminal 20 peptide
proAdm45-92adrenotensin
