膳食中抗氧化维生素摄入量与冠心病事件发病率的关系

Dietary antioxidant vitamins intake and incidence of coronary heart disease

探讨不同人群平均胡萝卜素及其他抗氧化维生素的摄入量与冠心病事件发病率的关系。方法在我国１３个人群中进行心血管病发病监测，并在抽样人群中进行了心血管病危险因素调查（包括膳食调查）。结果各人群胡萝卜素的平均摄入量（男性４２１～１４１６μｇ／１０００Ｋｃａｌ、女性５７３～２１１４μｇ／１０００Ｋｃａｌ）与冠心病事件标化发病率（男性１／１０万至１５４／１０万，女性０／１０万至７７／１０万）呈显著负相关（ｒ＝－０．４２３１，Ｐ＝０．０３）。在控制性别、人群平均体重指数、舒张压和血清总胆固醇后，多元直线回归分析显示人群胡萝卜素的平均摄入量仍与冠心病事件有显著的负关联（β＝－０．３５５６，Ｐ＝０．０１１８，Ｒ２＝０．８０）．结论增加人群中富含胡萝卜素的深色蔬菜的摄入量可能有助于冠心病的预防。

Objective To assess the relationship between incidence of coronary heart disease (CHD) anddietary intake of carotene and other antiokidant vitamins (Vit C, Vit E). Methods The incidence ofcardiovascular disease was monitored according to MONICA procedure among 100 000 residents in each of 13populations from different parts of China in 1991-1995. A random cluster sample of 1000 (35-59 years, men andwomen) was drawn from each population for survey of CHD risk factors with a 1/10 sub-samples for 3 consecutivedays 24-hour dietary interviews (dietary data was available for 13 populations). Results The age-standardized(25-74years) incidence of CHD was 1-154/100 000 for men and 0-75/100 000 for women among 13 populations.Only the mean daily intake of carotene (421 -1416 /1000 K cal, 573 -2114 /1000 Kcal for men andwomen) was significantly inversely correlated with the incidence of CHD (r=-0.423 1, P=0.03) by simplecorrelation analysis. The major sources of carotene were deep colored vegetables, which provided 38-91% ofcarotene ne among populations. The resultS of mulhple linear ~ion showed that ~ daily intake Of caIDtene andthe intake ratio of deep colored vegetables to total vegetables were significantly negatively associated with theincidence of CHD (b=-0.038 9, β=-0.355 6, P=0.01, R2=0.80; b=-55.501 4, =-0.273 4,P=0.03, R2=0.88, respectively) after adjustment for gender, mean BMI, serum TC and DBP. Conclusion Higher intake of carotene, which mainly comes from deep colored vegetables in Chinese diet, may decrease therisk of CHD in Chinese population. The effect was independent of population's mean levels of BMI, serum TC andDBP.