经皮冠状动脉腔内成形术前后血小板功能及前列腺素水平的变化及其临床意义

The clinical significance of the change in platelet function and prostaglandin level with PTCA

目的研究冠心病患者经皮冠状动脉腔内成形术（ＰＴＣＡ）前后，冠状循环中血小板的变化，为临床用药提供参考。方法由冠状静脉窦采血，采用放免方法检测ＰＴＣＡ术前后血小板表面α－颗粒胰蛋白（ＧＭＰ－１４０）分子数和血浆血栓素Ｂ２（ＴＸＢ２）、血浆６－酮－前列腺素Ｆ１α（６－酮－ＰＧＦ１α）浓度。结果２３例稳定心绞痛患者，１５例不稳定心绞痛患者ＰＴＣＡ术后５分钟血小板膜表面ＧＭＰ－１４０及血浆ＴＸＢ２明显增高，术后１０分钟达到高峰，３０分钟降至正常。结论冠心病患者ＰＴＣＡ术后确有血小板活化。

Objective To observe the active change of the platelet in the coronary circulation before andafter PTCA in the patients with coronary heart disease in order to provide a guide to clinical drug usage. MethodsBlood was obtained from the coronary sinus. Molecular amount of CMP-140 on the surface of platelet andconcentration of TXB2, 6-keto-PGF1α. in plasma were determined using radioimmunoassay. Results Both theamount of GMP-140 and the concentration of TXB2 were higher after PTCA than those before PTCA, rising to thepeak at 10 minutes, decreasing to the normal at 30 minutes. conchusion may be activated after PTCA.