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高血压不同时期β受体的变化及其意义 被引量:22

Changes of β-adrenoreceptors in peripheral lymphocytes at essential hypertension andtheir clinical significance.
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摘要 目的探讨高血压病(EH)患者心肌β受体的变化与其病情的关系。方法采用3H-双氢阿普洛尔(3H-dihydroalprenolol)放射性配基结合分析法,测定69例EH不同时期男性患者外周血淋巴细胞的β受体密度(与心肌β受体密度呈显著性正相关),并对各期10例患者进行羟甲叔丁肾上腺素药物实验,以测定β受体敏感性。结果Ⅰ、Ⅱ期EH患者β受体的最大结合容量(βMmax)分别较正常人增加30.8%(P<0.01)和56.7%(P<0.001),羟甲叔丁肾上腺素增加心率30次/分的变时剂量(CD30)分别较正常人降低20.7%(P<0.01)和37.9%(P<0.001),其中并发左室肥厚患者上述特征的显著性明显大于元左室肥厚患者(均P<0.001)。Ⅲ期EH患者βmax较正常人降低27.2%,CD30则较正常人增加24.1%(均P<0.01),其中井发心力衰竭患者上述特征的显著性明显大于无衰竭患者(均P<0.001)。结论心肌β受体密度及功能的变化可能与EH及其并发左室肥厚与心力衰竭有关,提示,该参数可作为判断EH患者病情变化的一项指标。 Objective To explore the relation of β-adrenoreceptor density and function to patient'scondition in patients with essential hypertension (EH). Methods Sixty-nine male patients with EH at differentstages were included in study and 30 healthy subjects were used as control. β-adrenoreceptor maximum boundvolume (βmax) in periphery lymphocytes was measured by 3H-dihydroalprenolol (3H-DHA) radio ligand binding.β-adrenoreceptor responsiveness was determined by Salbutamol (injection). Results βmax was significantly higherin patients with EH at stages Ⅰand Ⅱ (P<0.01 and P<0.001, respectively) and the chronotropic dose of Salbutamol required to increase heart rate by 30 beats/min (CD30) was significantly lower (P<0.01 and P<0.001), respectively) than that in control group. was significantly lower and CD30 was significantly higher (allP<0.01) in patients with EH at stage Ⅲ than there in coned group. β was signifiantly higher and CD30 wassignificantly lower (all P<0.001) in patients with EH with left ventricular hypertrophy (LVH) than in thosewithout LVH. βmax was significantly lower and CD30 was significantly higher (all P<0.001) in patients with EHand heart failure than inthose without heart failure. Conclusion β-adrenoreceptor plays a role in the pathogensisof hypertension, hypertension complicated with ventricular hypertrophy and heart failure. β-adrenoreceptor densityand function may be viewed as an index for evaluating hypertensive Patient's condition.
出处 《中华心血管病杂志》 CAS CSCD 北大核心 1999年第1期48-50,共3页 Chinese Journal of Cardiology
基金 河北省卫生厅科研基金!94008
关键词 高血压 Β受体 肾上腺素能 hypertension β-adrenoreceptor adrenergic
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参考文献3

  • 1单精瑞 付国辉 等.外周血液淋巴细胞肾上腺素能受体的放射性配合结合分析法[J].军事医学科学院院刊,1988,1:73-77.
  • 2单精瑞,军事医学科学院院刊,1988年,1卷,73页
  • 3Michel M C,J Auto Pharmacol,1987年,7卷,41页

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