奥氮平与阿立哌唑治疗难治性精神分裂症70例的对照研究

Comparative study between olanzapine and aripiprazole in treatment of refractory schizophrenia

目的:比较奥氮平与阿立哌唑对难治性精神分裂症的疗效与不良反应。方法:将70例难治性精神分裂症患者随机分为两组,每组各35例,分别给予奥氮平和阿立哌唑治疗,疗程12周,用阳性症状和阴性症状量表(PANSS)评定疗效,用副反应量表(TESS)评定不良反应。结果:奥氮平治疗有效率为62.9%,阿立哌唑为60%,两组总体疗效比较差异无统计学意义(P>0.05)。奥氮平组主要不良反应为体重增加、血糖升高;阿立哌唑组主要为失眠、头痛。结论:奥氮平与阿立哌唑对难治性精神分裂症疗效相当,不良反应较少。

Objective： To study the clinical efficacy and side effects of olanzapine and aripiprazole in the treatment of refractory schizophrenic patients. Methods：A total of 70 patients with refractory schizophrenic were randomly divided into two groups , respec- tively, for olanzapine and aripiprazole treatment, treatment for 12 weeks, with Positive Symptoms and Negative Symptoms Scale （PAN- SS） assessment of efficacy, adverse reactions with the scale （TESS） assessment of adverse reactions. Results： Olanzapine in the treat- ment response rate was62.9 %, aripiprazole 60% ,overall efficacy difference between the two groups was not statistically significant （p 〉 0.05 ）. The side effects of olanzapine were increased weight and blood glucose levels, The side effects of aripiprazole were insomnia and headache. Conclusions： Olanzapine and aripiprazole are similar in the treatment of refractory schizophrenic, with fewer side effects.