舍曲林与马普替林对抑郁症患者112例生活质量对照研究

A comparative study of quality of in depression with Sertraline and Maprotiline

目的:探讨舍曲林、马普替林对抑郁症患者生活质量的影响。方法:对符合CCMD-3诊断标准的抑郁症患者随机分为两组,每组56人,分别使用舍曲林、马普替林治疗2个月,用汉密顿抑郁量表(HAMD)观察患者的抑郁情绪,用药物副反应量表(TESS)评定不良反应的严重程度,用生活质量综合量表(GQOLI-74)评定患者生活质量。结果:舍曲林在改善患者抑郁情绪方面与马普替林相当,而舍曲林不良反应少且轻。2月末,治疗前后相比,舍曲林对患者的生活质量的影响,除物质生活纬度外,均明显改善(P<0.01)。马普替林组除对心理功能有提高外,对躯体功能、社会功能均无改善(P>0.05)。结论:舍曲林对改善抑郁症患者生活质量优于马普替林。

Objective：To explore the effect of qulity of life in depression with Sertraline and Maprotiline. Methods：the patient that consistent the diagnostic criteria of depression in CCMD - 3 were randomized into two group 56cases. The course of treatment was 2 months . Before and after the treatment, the depressymptoms were evaluated by HAMD, the side effects were evaluated by TESS and the qulity of life were evaluated by （ QOLI - 74. ）. Results： The curative effect to improve despress symptoms in Sertraline group was e- quivalency with Maprotiline group. The side effects in Sertraline group were fewer and lighter than Maprotiline group. After 2 months treatment（ p 〈 0.01 ） , the effect of qulity of life in Sertraline group was getting light to except material life factor（ （ p 〉 0.05 ）. Conclu- sions： Sertraline is more useful for improving the qulity of life of depressive patient than . Maprotiline.