西酞普兰和氟西汀治疗老年期抑郁症的对照研究

Comparative study of citalopram and flouxetine in the treatment of patients with senile depression

目的:比较西酞普兰与氟西汀治疗老年期抑郁症的临床疗效和安全性。方法:对60例符合CCMD-3抑郁症诊断标准的老年患者随机分为两组,分别应用西酞普兰和氟西汀进行治疗,疗程6周,采用汉密尔顿抑郁量表(HAMD)和副反应量表(TESS)评定疗效和不良反应。结果:西酞普兰组显效率为76.4%,氟西汀组显效率为73.3%,两组疗效相仿,但西酞普兰起效较快,不良反应较轻。结论:西酞普兰是一种安全有效,起效快,不良反应轻的抗抑郁药物。

Objective： To compare the efficacy and side effects of citalopram and flouxetine in the treatment of patients with se- nile depression. Methods：60 patients with senile depression were randomly assigned to two groups, one group was treated with citalo- pram and the other with flouxetin for 6 weeks . The efficacy was assessed with Hamilton depression scale （HAMD） and the side effect was evaluated with treatment emergent symptoms cale （TESS）. Results： After six weeks treatment, the significant improvement rate of citalopram and flouxetin group were 76.4% and 73.3%. Two drugs had similar efficacy, but citalopram took effects more quickly. Conclusions： Citalopram is a safe and effective drug with few side effects in the in the treatment of senile depression.