清远市区2008年狂犬病疫苗免疫监测结果分析

Monitoring Results of Rabies Vaccination in Urban Qinyuan City in 2008

目的了解狂犬疫苗免疫后效果,为预防和控制狂犬病提供依据。方法采用酶联免疫吸附试验(ELISA)法检测免疫注射狂犬疫苗后人群的人狂犬病病毒IgG抗体水平。结果接受全程(1个免疫程序)免疫的人群狂犬病病毒IgG抗体阳性率为99.18%(973/981),其中男性阳性率为98.62%(572/580),女性阳性率为100%(401/401),男女性别的阳性率比较,差异有统计学意义(χ2=4.0016,P<0.05)。对狂犬病病毒IgG抗体未阳转者再注射3针后全部阳转。结论注射狂犬疫苗1个免疫程序,未能达到100%的免疫效果。对注射狂犬疫苗免疫后的人群,有必要进行人狂犬病病毒IgG抗体水平监测,以便及时补种,以达到满意的免疫效果。

[Objective]To understand the immune effect of rabies vaccine,and provide evidence for prevention and control of rabies.[Methods]Rabies Virus IgG levels were detected by ELISA after immunization.[Results]Rabies virus IgG positive rate of people who accepted full immunization was 99.18%（973/981）,the male positive rate was 98.62%（572/580）,and female positive rate was 100%（401/401）,The difference was significant between genders（χ2=4.0016,P0.05）.The negative IgG antibody against rabies virus changed to positive after immunization of 3 doses.[Conclusion]The immunological effect can not reach 100% after a full immunization program of rabies vaccine.The population with rabies vaccine immunization should receive IgG antibody level monitoring for necessary renewed vaccination timely to achieve satisfactory immune effect.