舒血宁联合脑蛋白水解物治疗急性脑梗死的疗效观察

Effect of combined therapy of Shuxuening and brain protein hydrolysate on acute cerebral infarction

目的：观察舒血宁注射液联合脑蛋白水解物治疗急性脑梗死的临床效果。方法：将70例急性脑梗死患者,随机分成治疗组与对照组,每组各35例,两组均常规给予拜阿斯匹林0.1 g,每日1次,尼莫地平20 mg每日3次口服;对照组主要药物为盐酸川芎嗪、胞二磷胆碱、右旋糖酐40等,疗程10-14d;治疗组在口服拜阿斯匹林、尼莫地平基础上,应用生理盐水100 mL＋脑蛋白水解物60 mg、生理盐水250 mL＋舒血宁20 mL静滴,10-14 d为一疗程。比较两组治疗前、后的血液流变学改变和疗效。结果：治疗组患者血流变学各指标在治疗前、后差异均有显著性意义（P〈0.05）。治疗后14 d疗效评定,治疗组总有效率为88.57%,对照组总有效率为68.57%,两组比较差异有显著性意义（P〈0.05）。结论：舒血宁注射液联合脑蛋白水解物治疗急性脑梗死比传统的低右＋川芎嗪疗效更显著,且安全可靠。

Objective： To observe effect of combined therapy of Shuxuening and brain protein hydrolysate on acute cerebral infarction（ACI）.Methods： Randomly divided 70 ACI cases into treatment group and control group with 30 cases each group.Treated both groups with 0.1 mg aspirin 3 times a day and 20 mg Nimodipine 1 time a day.Besides,treated control group with tetramethylpyrazine hydrochloride 40 mg,citicoline 40 mg,and dextran 40 mg for 10-14 days,while treatment group with saline 100 mL＋brain protein hydrolysate 60 mg and saline 250 mL＋Shuxuening 20 mL for 10-14 days.Compared the hemorrheological indexes and clinic effect.Results： There were significant differences in hemorrheological indexes before and after therapy in treatment group（P〈0.05）.The total efficacy was 88.57% in treatment group and 68.57% in control group with significant difference（P〈0.05）.Conclusion： Combined therapy of Shuxuening injection and brain protein hydrolysate is more effective and safe.