氯吡格雷联合阿司匹林治疗非ST段抬高急性冠状动脉综合征的疗效

Effects of clopidogrel in combination with aspirin on acute non-ST-segment elevation coronary syndrome

目的:运用氯吡格雷联合阿司匹林治疗非ST段抬高急性冠状动脉综合征,对比观察临床疗效。方法:收集我院诊治的非ST段抬高急性冠状动脉综合征患者100例,随机分为治疗组51例和对照组49例,对照组在常规治疗基础上加用标准剂量的阿司匹林,治疗组则在对照组基础上给予氯吡格雷治疗,连续治疗2个月,观察两组的临床疗效、统计心血管事件发生、检测凝血功能及血小板计数变化、记录药物的不良反应。结果:治疗组的临床疗效和心电图疗效均显著高于对照组(P<0.01),治疗组的心血管事件发生率也较对照组低(P<0.05)。但凝血功能及血小板计数两组间差异无统计学意义(P>0.05),两组均未见严重的不良反应。结论:氯吡格雷联合阿司匹林治疗非ST段抬高急性冠状动脉综合征疗效要优于单用阿司匹林,且安全性良好,二者联合可长期使用。

Objective： To observe effects of clopidogrel in combination with aspirin on non-ST-segment elevation acute coronary syndrome.Methods： A total of 100 patients with non-ST-segment elevation acute coronary syndrome,were randomly divided into treatment group（51 cases） and control group（49 cases）.Both groups were treated with conventional therapy combined with standard dose of aspirin for a consecutive 2 months,while the treatment group was also given with an extra clopidogrel treatment.Therapeutic effects and adverse drug reactions of these 2 groups were observed,cardiovascular events calculated,changes of coagulation function and platelet counts before and after the treatment were recorded.Results： Both the clinical efficacy and ECG improvement shown in the treatment group were significantly better than that in the treatment group（P〈0.01）.The incidence of cardiovascular events of treatment group was lower than that of the control group（P〈0.05）,while there was no significant difference between the changes of coagulation function and platelet counts of the two groups（P〉0.05）.Conclusion： Clopidogrel in combination with aspirin,which is safe and suitable for long-term use,shows better effects on non-ST-segment elevation acute coronary syndrome than aspirin alone.