糖尿病患者血小板参数的水平观察和初步分析

Observation and preliminary analysis of blood platelet parameters in diabetes patients

目的:探讨糖尿病患者微血管病变与血小板各参数的关系。方法:采用XE-2100型全自动五分类血细胞分析仪同时对110例糖尿病患者(其中有微血管病变63例,无微血管病变47例)和70例健康对照组进行血小板计数(PLT)、血小板平均体积(MPV)、血小板分布宽度(PDW)、血小板压积(PCT)、大血小板比率(P-LCR)测定;采用日本AU2700全自动生化分析仪应用葡萄糖氧化酶法检测空腹血糖(FPG)。结果:糖尿病患者MPV、PDW、PCT、P-LCR均明显高于正常对照组(P<0.01);有微血管病变组MPV、PDW、P-LCR均明显增高(P<0.01);且MPV与FPG呈正相关(r=0.55,P<0.01)。结论:密切观察糖尿病患者的MPV、PDW、P-LCR值,可以为早期预示糖尿病微血管病变的发生提供线索。

Objective： To discuss the relations of microvessel pathological change and various parameters of blood platelet in diabetes patients.Methods： One hundred and ten diabetic cases including 63 cases with microvessel pathological changes and 47 without changes,and 70 healthy cases were selected.The XE-2100 entire automatic five classifications blood corpuscle analyzer was used to test indexes such as platelet count（PLT）,blood platelet average volume（MPV）,blood platelet distribution width（PDW）,blood platelet pressure accumulates（PCT）,and big blood platelet ratio（P-LCR）,while Japanese AU2700 entire automatic biochemistry analyzer was applied to determine empty stomach blood sugar（FPG） with glucose oxydase law examination.Results： MPV,PDW,PCT,P-LCR in diabetes patient were significantly higher than normal comparison group（P〈0.01）.Patients with microvessel pathological change had significant higher MPV,PDW and P-LCR（P〈0.01）,and there was positive correlation between MPV and FPG（r=0.55,P〈0.01）.Conclusion： Close observation of MPV,PDW,the P-LCR value can provide evidence for the early diagnosis of microvessel pathological change in diabetes patients.