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哮喘对吸入性糖皮质激素治疗反应性与肥胖的关系 被引量：4

Body mass and glucocorticoid response in asthma
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摘要 目的研究体重与肺功能的关系,及哮喘对糖皮质激素的反应性。方法将纳入患者根据BM I分组,给予吸入性糖皮质激素(GCs),定期随访并监测肺功能变化情况。结果①超重及肥胖组的肺功能测量值明显低于消瘦及体重正常组,差异有统计学意义(P<0.05);②超重及肥胖组治疗2周及1个月检测肺功能好转情况均低于消瘦及体重正常组,差异有统计学意义(P<0.05);③超重及肥胖组在各治疗阶段未控制率均高于消瘦及体重正常组,差异有统计学意义(P<0.05)。结论肥胖和超重者的哮喘症状比体重正常者重,其对GCs的反应性也比体重正常者低。 Objective To investigate the relationship between obesity and asthma,and the relationship between obesity and glucocorticoid response in asthma.MethedsA total of 121 petients were divided into three groups,All of them were given Inhaled Corticosteroids,regular followed-up and monitoring their pulmonary function.Results Overweight/obese asthmatic subjects demonstrated small differences in FEV1 and FEV1/FVC% 1evels（P0.05）.Overweight/obese asthmatic subjects demonstrated a smaller improvement in FEV1,and FEV1/FVC% levels with inhaled corticosteroid（ICS）treatment（P0.05）.Conclusion The symptoms of the overweight/obese asthmatic subjects were worse than others,and the overweight/obese asthmatic subjects were insensitive of inhaled corticosteroid.
作者 任世友 任世琼 李娜 孙建
机构地区 凉山州第一人民医院马道分院 攀枝花市中心医院内科 四川大学华西医院呼吸内科
出处 《四川医学》 CAS 2010年第5期622-624,共3页 Sichuan Medical Journal
关键词 哮喘 肥胖 糖皮质激素 asthma obesity glucocorticosteroid
分类号 R562.25 [医药卫生—呼吸系统]
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参考文献9

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同被引文献32

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四川医学
2010年 第5期

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