支气管哮喘症状长期缓解患者肺功能与气道炎症的关系

Correlation between Pulmonary Function and Airway Inflammation in Long Term Remission Patients with Bronchial Asthma

目的:探讨支气管哮喘临床症状长期缓解患者肺功能与气道炎症的关系。方法:20例成年支气管哮喘临床缓解期患者行肺功能测定,酶联免疫吸附法(ELISA)测定外周血干扰素-γ(IFN-γ)、白细胞介素-4(IL-4)水平,并与47例健康体检者进行比较。结果:哮喘缓解期患者(FEV1/FVC)%<70%者13例,FEV1<80%预计值者14例,FEV1、PEF、FEF25、FEF50、FEF75显著低于对照组(P<0.01)。哮喘患者血浆IL-4水平显著高于对照组(P<0.01),IFN-γ/IL-4显著降低(P<0.05)。IFN-γ/IL-4与FEV1、PEF呈显著负相关(P<0.01)。结论:临床症状长期缓解的哮喘患者仍可能存在肺功能损害,气道炎症和Th1/Th2平衡紊乱持续存在。

Objective To investigate the correlation between pulmonary function and the levels of inflammatory factors in serum of long term remission patients with bronchial asthma.Methods The pulmonary function were determined in 20 cases of adult asthmatic patients with long term remission,the serum levels of IFN-γ and IL-4 in those patients were determined with ELISA,47 cases of healthy volunteers were selected as control group.Results There were 13 cases that the values of （FEV1/FVC）% were lower than 70% and 14 cases that the values of FEV1 were lower than 80% predicted value in 20 asthmatic patients,and FEVl,PEF,FEF25,FEF50,FEF75 were all significantly lower than those of control group（P0.01）.The serum level of IL-4 was significantly higher than that of control group（P0.01）,IFN-γ/IL-4 was significantly decreased（P0.05）.IFN-γ/IL-4 were negatively correlated with both FEV1 and PEF （Pall0.01）.Conclusion Although through a long term remission,the pulmonary function injury,airway inflammation and imbalance of Th1/Th2 may still exist in asthmatic patients.