HBV-DNA在不同性别间的分布特征分析

Analysis on Distributional Characteristics of HBV-DNA among Each Gender

目的了解乙肝患者不同性别间HBV-DNA分布特征。方法荧光定量PCR用于定量检测21 650例乙肝患者HBV-DNA。结果男性和女性HBV-DNA总阳性率分别为61.22%和53.47%(χ2=119.50,P<0.000 1),男性和女性阳性率均逐年增高(分别为r=0.857 14,P=0.006 53和r=0.809 52,P=0.014 9),病毒载量均逐年下降(分别为r=-0.904 8,P=0.002 01和r=-0.857 1,P=0.006 53)。出现由高拷贝峰值的单峰分布到低拷贝峰值高拷贝为亚峰的双峰分布的特征。结论 HBV-DNA阳性率男性显著高于女性;两性阳性率均逐年增高,病毒载量均值均逐年下降;病毒载量无性别差异。

Objective To realize the distributional characteristics of HBV-DNA among each gender.Methods HBV-DNA of 21650 patients with hepatitis B was determined by real-time PCR.Results The total positive rate in male and female was 61.22% and 53.47% respectively（χ2=119.50,P0.000 1）.The positive rate increased year by year in male and female（r=0.857 14,P=0.006 53 and r=0.809 52,P=0.014 9 respectively）.The viral load decreased year by year in male and female（r=-0.904 8,P=0.002 01 and r=-0.857 1,P=0.006 53 respectively）.The distributional characteristics showed as unimodal distribution with high copy peak value to bimodal distribution with low copy peak value and high copy peak value.Conclusions The positive rate of HBV-DNA is higher in male than in female,and increases year by year in male and female.The viral load decreases year by year in male and female without sexual difference.