糖链抗原50测定在肺癌中的应用

CLINICAL VALUE OF DETERMINATION OF CA50 IN SERUM OF PATIENTS WITH LUNG CANCER

采用免疫放射分析法检测７０例肺癌患者血清糖链抗原５０（ＣＡ５０）。结果表明，肺癌患者血清ＣＡ５０明显升高，与非癌性肺病组相比差异非常显著（Ｐ〈０．０１），且ＣＡ５０含量随肿瘤进展而上升，以１７Ｕ／ｍｌ为阻性界值，诊断肺癌的敏感性为６８．６％，特异性为９０．６％，ＣＡ５０检测可作为肺癌辅助诊断，病情监测的手段。

Objective:In order to evalute usefulness of CA50 as lung cancer marker.Methods:CA50 was measured in the serum of 70 patients with lung cancer by the method of immuoradiotric assay (IRMA).Results:CA50 levels of cancer patients was significantly higher than those of controls (P<0.01).There was correlation between CA50 levels and tumor-node-metastasis (TNM) stage.At a cut off value of 17U/ml,the sensitivity and specificity were 68.6% and 90.6%,respectively.Conclusions:CA50 could be used as lung cancer marker in the aid-diagnosis and monitorning the clinical course.