影响老年原发性高血压脉压的相关因素分析

The study of related factors of pulse pressure in elderly patients with essential hypertension

目的探讨老年原发性高血压(EH)相关因素与脉压(PP)的关系。方法通过对2003～2007年住院治疗的老年高血压病患者309例(男185例,女124例)进行回顾性调查,按脉压(PP)≤60mmHg、60<PP≤100mmHg、PP>100mmHg分为三个组,分析各组的脉压与性别、高血压病程、体重指数(BMI)、收缩压(SBP)、舒张压(DBP)、血糖、血脂、左室重量指数(LVMI)、射血分数(EF)、左室短轴缩短率(FS)、颈动脉斑块的相关性。结果各组BMI、血糖、甘油三脂(TG)、胆固醇(TC)、低密度脂蛋白(LDL)无明显差异(P>0.05);脉压与SBP(r=0.48)、年龄(r=0.25)、高血压病程(r=0.23)、LVMI(r=0.65)、颈动脉斑块(r=0.69)、EF(r=0.31)呈正相关(P均<0.01),而与DBP(r=-0.90)、FS(r=-0.35)、高密度脂蛋白(HDL)(r=-0.22)呈负相关(P均<0.01)。结论资料显示脉压与年龄、高血压病程、SBP、DBP、EF、FS、高密度脂蛋白、LVMI、颈动脉斑块等因素密切相关。

Objective To expore the relationship between the related factors and pulse pressure（PP） of the elderly patients with essential hypertension （EH）. Methods A retrospective investigation of 309 hospitalized patients with EH （male 185 cases, 124 cases of women） from 2003 to 2007 were performed, In accordance with PP≤60 mmHg, 60 〈 PP≤100 mmHg,PP 〉 100 mmHg,the patients were divided into 3 groups. In each group,the correlation of PP with sex,hypertension course, body mass index （ BMI）, SBP,DBP, blood glucose, blood lipids, LVMI, EF, FS, carotid artery plaque were annalyzed. Results There was no correlation of PP with the BMI, blood glucose, triglyceride （TG）, cholesterol （ TC）, low density lipoprotein （LDL） （ P 〉 0. 05 ） ; There were positive correlations of PP with age, hypertension course, SBP, LVMI, carotid artery plaque, EF（r =0.25,0.23,0. 48, 0. 65,0. 69, 0. 31, P all 〈 0. 01 ）, while there was negative correlation of PP with DBP, FS, high-density lipoprotein （HDL） （r = - 0. 90, - 0. 35, - 0. 22,P all 〈 0. 01 ）. Conclusion There is correlation of PP with age, duration of hypertension, SBP, DBP, EF,FS, HDL, LVMI, carotid artery plaque